ZEBRAFISH IGF GENES: GENE DUPLICATION, CONSERVATION AND DIVERGENCE, AND NOVEL ROLES IN MIDLINE AND NOTOCHORD DEVELOPMENT.

Zebrafish IGF genes: gene duplication, conservation and divergence, and novel roles in midline and notochord development.

Insulin-like growth factors (IGFs) are key regulators of development, growth, and longevity.In most vertebrate species including humans, there is one IGF-1 gene and one IGF-2 gene.Here we report the identification and functional characterization of 4 distinct IGF genes (termed as igf-1a, -1b, -2a, and -2b) in zebrafish.These genes encode 4 structur

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New contraceptive eligibility checklists for provision of combined oral contraceptives and depot-medroxyprogesterone acetate in community-based programmes

Community-based services (CBS) have long used checklists to determine eligibility for contraceptive method use, in particular for combined oral contraceptives (COCs) and the 3-month injectable contraceptive depot-medroxyprogesterone acetate (DMPA).As safety information changes, however, checklists can quickly become outdated.Inconsistent checklists

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